The aim of this study was to determine the efficacy of an evidence-based opioid guidelines-based program implemented at the largest worker’s compensation insurer in Utah. This program significantly reduced the usage of opioids among acute claims. The year of program implementation, Utah experienced a 19.8% reduction in opioid-related fatalities, which may be partly related to the reduction in MEDs. Regardless, this study suggests that the implementation of an evidence-based guideline is impactful and feasible.